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Ancient Greece is a uniquely preserved culture we know much about through study and research. Greek mythical figures and beast

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s played a pivotal role in Greek society and folklore at that time.

The Mythical Figures and Beasts of Ancient Greece

While

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

gods and goddesses may have been the most important beings in Greek mythology, there were many other characters that were esse

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tial to these tales. Mortals were very important in Greek myths; without them, there would be no one for the gods and goddesse

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s to “play with”. Also integral were Greek mythical figures – these fantasy animals and partially human beings served a vital

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ole in the myths that were told during this time.

One of the most talked about mythical figures of all time has to be Medusa.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Depicted as a woman with snakes on her head instead of hair, the story of Medusa begins with a mortal woman. It is said that

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Medusa was so beautiful as a young girl, her looks enchanted Poseidon, and turned his attention away from Athena. This angered

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Athena so much that she changed Medusa into a gorgon, a mythical beast with snakes for hair and a face so hideous that it turn

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ed anyone who looked at it into stone. This was not enough revenge for Athena, and later she guided Perseus to find Medusa and

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

kill her.

Another of the major Greek mythical beasts was Cerberus, the three-headed dog. This animal was the offspring of Typ

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

hoeus (an immortal storm giant) and Echidna, a monster that was half human and half snake. Cerberus had three dog heads, a sna

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ke's tail, and snakes protruding from its monstrous back. Cerberus's position was at the entrance to the underworld, where he

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

llowed the dead to enter but not to leave. Only a few living mortals were ever able to get past Cerberus, including Orpheus, w

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ho charmed him to sleep with music.

A final look at Greek mythical beasts comes up with Hecatoncheires, literally translated

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s the “hundred handed”. Three of these existed, named Aegaeon, Cottus, and Gyges. Born to Gaea and Uranus, they hated their fa

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ther so much that Uranus was forced to imprison the Hecatoncheires back into Gaea's womb. They were later released by Zeus, wh

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

en he was fighting against the Titans; they were able to hurl a hundred boulders at a time at their opponents.

There were man

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lesser Greek mythical figures and beasts as well, and there was a definite hierarchy among the different mythical characters.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

These animals and sometimes human hybrids made up the majority of the story lines that went along with the gods and goddesses

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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