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The Search dog handler who trains on a weekly basis in the same place or rotates a few favorite spots is not presenting an effective training situation

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

for himself or his dog. Use of the same scenarios regularly becomes too familiar for the dog and do not present the challenges necessary to prepare the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

dog for unfamiliar territory. In order to be mission ready, a search dog must be ready to face new or unusual situations without hesitation. Search do

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

handlers should make every effort to expose their dog during training to a large variety of different conditions. It is for this reason that a Search

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

og training "class" often is not the best solution for training a search dog. It is almost impossible to present a "class" which will cover the various

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

terrain areas, climatic conditions and other factors, which should be included in the training of a search dog. The best solution to this training prob

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lem is to make sure that the handler has at least ten different locales large enough that he can train on a different one every week and in a different

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rea, for at least ten weeks and that he sets up his scenarios as often as possible for different times of the day and in different weather conditions.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Furthermore, the considerations of whether or not the land being used is private or public land where no hunting is allowed and/or where permission has

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

een given to use the land are important considerations and must be taken into account.

When finding suitable terrain to practice on, the search dog han

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ler should expose the dog from the beginning to many different locales. The terrain is what changes the way the scent reaches a dog's nose, for one thi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ng. A field of alfalfa or a grove of pine trees, for example, present scent fields, which may be so strong as to make it difficult for the dog to discr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

minate the scent of a human being within the area. For another thing, the "lay of the land" can present difficulties of maneuvering through the area, w

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ich the dog must be able to overcome. A search dog should be willing and ready to go through thickets and brambles, up and down steep valleys and narro

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ridges, slippery rock surfaces and through creeks and streams, not to mention over, under, or through man made obstacles such as fences. Also the cont

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

mination of the land being used, whether or not it is a heavily populated area as far as wild life or as far as human usage, is important, so that the h

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

andler knows that the dog has been exposed to the many varied scents of wild animals or areas which are heavily contaminated with residual scents.

Anot

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

er consideration when training is to present the dog with as many climatic problems as possible. Foggy days, hot and humid days, strong wind conditions

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

night time versus day time scenarios....all the possible varieties of environmental conditions that you can possibly expose your dog to during the trai

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ing situation can lead to a higher probability that you and your dog can successfully handle all the possible eventualities which can occur on a mission

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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