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The saltwater aquarium is not recommended for the beginner aquarist. It is however uncommon for beginner aquarists to even wish to start out with a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

saltwater aquarium instead of a freshwater aquarium. Setting up a basic saltwater aquarium is much more expensive than setting up a basic freshwat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r aquarium, and this means that it is typically the dedicated aquarist with years of freshwater experience that decides to spend the necessary mone

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

on a saltwater aquarium. The film “Finding Nemo” did however cause a saltwater boom, since a lot of people who saw the film wanted to keep a “Nemo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

fish”, i.e. a marine clownfish. Unfortunately, a lot of clownfishes ended up in the hands of unsuitable keepers that weren’t prepared to spend enou

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

h time, effort and money on their new pet. If you are a comparatively inexperienced aquarist, you can still become a highly successful saltwater aq

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

uarist if you are prepared to spend a lot of time and energy on learning how a saltwater aquarium really works. Investing in suitable equipment and

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

choosing some of the hardiest saltwater species will also greatly increase your chance of success. Do not hesitate to contact a saltwater aquarium

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

lub or a saltwater aquarium forum online and ask for advice and guidelines. Most saltwater aquarists are happy to share their knowledge with new as

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

iring saltwater aquarists.

One of the reasons why saltwater aquariums are more difficult to maintain than freshwater aquariums is that marine spec

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es tend to be much less tolerant to organic waste products and other forms of pollution. The enormous water mass that constitutes the ocean will ra

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

pidly dilute organic waste down to very low levels. Marine creatures are therefore not used to high levels of soluble waste and do not know how to

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ope. There are of course many freshwater species to be found that are also highly sensitive to organic waste and very difficult to keep in aquarium

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

. Generally speaking, it is however much easier to find sturdy freshwater species since freshwater fish can live in small lakes and even puddles wh

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

re the levels of organic waste can reach very high levels. Compared to marine species, these fishes will also typically be more suited to cope with

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

all forms of change. In a smaller body of water, the temperature can for instance shift rapidly. Water hardiness and pH can also be affected by ext

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ernal factors. Trying to keep the environment in a freshwater aquarium as stable as possible is therefore good training if you plan on setting up a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

saltwater aquarium in the future.

The overall chemistry and ecology are also different in a saltwater aquarium, since the presence of salt affects

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

chemical as well as biological processes. This is however not only a problem, it is also a possibility. You will for instance be able to use a prot

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

in skimmer in a saltwater aquarium; a very powerful form of filtration that will remove tiny organic waste particles before they begin to decompose

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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