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Halloween decorating can be a lot of fun for both the creator and the neighborhood. There are a lot of options for those who like to decorate their yard for this be-a-kid day, uh, night. Many different people either go all out or simply hang a paper skeleton on their fro

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nt window. For those that go all out, the neighbor kids will gravitate to your place, so there will not be a shortage of ghosts, goblins and ghouls stopping by on October 31st.

One extremely fun type of decor is to make your front-yard into a grave yard. One can go comp

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

letely elaborate with lighting, sound, lots of head-stones and even a mausoleum. However, you can start simple and do lots of grave-stones with very little effort and creativity. Head stones, grave stones and grave markers have been around since the dawn of time and have

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

always been “markers” for the buried. They also can form the creep affect which is paramount on Halloween. If you’re semi-creative or very creative you can have lots of fun making head stones.

To start, head over to your favorite lumber yard or home improvement center.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Locate the insulation isle and find the pink or blue sheets of foam insulation. Your best bet is to use either the 1 1/2 or 2 inch sheets. Either size will work and color is irrelevant as you’ll be painting over them anyway.

Once you have your trusty sheet of foam home

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

and in the garage, you’ll need to find some stencils and/or pictures by perusing the web or just about any source where graves are displayed. There are tons of head-stone and grave yard sites that can tickle your idea and imagination bone. If you don’t have a reference,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

your town probably has a cemetery near by. A digital camera and a nicely lit day work just as well. Of course, the other more creative approach, a favorite, is to completely make up the shapes from memory. Everyone has been to a grave yard at one time or another, so the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

re are plenty of references. Each sheet should yield about 6 to 8 head stones which is usually plenty to get started.

Cutting extruded styrofoam can be very easy and while there are several ways to perform the cutting, a large kitchen knife usually reserved for that lar

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ge watermelon during the summer will work just fine. Knives tend to leave rough edges and that’s fine for when you want that very old look which is common in grave yards. Other cutting tools that can be used are special styrofoam electric cutters that you can find on the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

web as well as there are several sites that offer a “How-To” on making your own cutter with a soldering iron and some heavy copper wire.

Now that you’ve cut out your head stone shape, you’ll want to put some kind of writing, eulogy or some kind of markings. Here a wood

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

burning tool works good, a sharp utility knife or a set of those craft knives with a variety of blades. For lettering you can either use some kind of stencil set and or print something from your favorite word processor. Either way, you can either go authentic or funny.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Draw an outline of the wording, drawing or date onto the front of the head-stone and cut out the lettering causing an embossing affect. If you have a wood burner and are familiar with it’s use, you can simply melt out the letters. Embossing the wording, lettering or date

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

give it a 3-D affect and an authentic look. Plus, at night, it adds a creepy affect if lighting is involved. For added interest, use a friend or neighbors name to add that extra touch. However, make sure they’re a good friend and not someone you really want to see burie

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d. That could lead to a whole other set of problems.

After all of the prep work is done by cutting your shape, adding your wording or markings, you’ll need to prepare it for presentation. With any type of sandpaper, clean the entire surface and make sure the cut edges a

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

re void of any extra pieces hanging where your knife did the cut. Now that it’s clean and ready, you should use a “latex” paint to prime or cover the entire surface. Latex paint creates both a barrier and surface for the final coloring. Use a light or white latex that ca

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n be found on the “Oops” shelf at just about any home improvement center.

Let the prime paint dry before going onto the final coat. Once dry, you now have several fine finish choices to wrap up the project. One technique is to spray water on the primed surface and light

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ly spray a black or gray paint letting it drip down through the cracks and surface of the head-stone. You can also “dry” brush getting the same affect by taking a light gray or darker colored paint and lightly applying it on the corners, in the engraved writing or in cra

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

cks. Taking a dry paint brush, lightly swipe in a downward fashion the dark paint until it creates streaks on the lighter surface.

For added affects, you can also add moss found in any hobby shop or where ever dried flowers or model trains are sold. This takes a lot mor

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e patience and simply painting should do the trick. For that perfectionist, cracks, additional coloring and the moss affect can really take it to the next level.

Once your first one is done, repeat until you have enough to make your own yard of head-stones. Putting a gr

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ave yard in your own front yard for Halloween can be both fun and rewarding if you anticipate lots of trick-er-treaters. Typically, the kids love the added affect and will definitely stop by your house to relieve you of the enormous amount of candy you have at the ready.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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