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Purchasing a home spa is a great expense; which can be easily wasted if you don’t keep your hot tub in good condition. Hot tubs

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

provide an area for you to relax and unwind at the end of the day. They also provide a luxurious place to entertain guests. That

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

being said, like your house, you want your hot tub to be clean when others are relaxing in it.

The following illustrates tips a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

d procedures that will help to ensure that your hot tub remains in good condition:

Recommended Procedures for Hot Tub Maintenan

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Check and regulate the sanitizer level as required.
Monitor the PH level to ensure it

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s at a safe and appropriate level.

Check the water line with water cleaning paste.

On a Weekly Basis

Oxidize the hot

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tub with non-chlorine shock.

Add no-foaming lotion to reduce the amount of foaming in your tub.

Check the calcium hard

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ess.

On a Monthly Basis

Using a cartridge cleaner, clean the filter cartridge.

Check the water balance by taking a w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ter sample. Along with the procedures above, there are also a number of things to remember to do whenever you change or

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

op-up the water in your hot tub. The three most importance hot tub maintenance procedures are - balance, sanitization and oxidiz

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tion of the water in your hot tub.

Water Balance – Water balance ensures that your hot tub maintains an ideal comfort

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

-level for everyone in the tub. It also ensures the chemical efficiency is up to par. Calcium hardness, total alkalinity and pH

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

evels are all key factors to maintaining water balance. Here are the appropriate levels for each of the elements:

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ium Harness – Between 100-200mg/l

Total Alkalinity – Between 125-150mg/l

pH Levels – Between 7.4 and 7.6

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nitization – Sanitizing your hot tub kills any bacteria that might be living in there. It also aids in the prevention of algae g

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

owth and the overall safety of your hot tub. The sanitization level should be monitored on a regular basis using test strips; wh

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ich are available in bromine and chlorine forms. Here are the appropriate levels for bromine and chlorine:

Bromine –

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

etween 3-6mg/l

Chlorine – Between 3-5mg/l

Oxidization – In order for your hot tub and spa to remain clean, you

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ust oxidize it on a weekly basis using non-chlorine shock. Oxidizing increases the comfort for bathers. It also gives the water

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

little extra sparkle. Follow these steps to ensure a clean, well maintained hot tub for you and your friends to enjoy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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