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Hotels are typically our first option when choosing vacation accommodations. This is no surprise. Where else would we

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

stay? Everyone knows that when you are out of town, you stay in a hotel. We see them on the side of the road and litte

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ing the beaches. Hotels are advertised on every travel website. So when we plan our family vacations, our goal is ofte

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n limited to simply getting the best price on a "hotel." And that we do. We are proud of ourselves and our $100 a nigh

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

accommodations.

The hotel room is not a shocker. We know what to expect. We are immediately greeted with the bathroo

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

. Straight ahead is the window with those one-inch thick curtains. To the right is the bed (or maybe two). We are happ

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

y when there is a nice chair with a table next to it. We are really living in luxury if there is a private bedroom, bu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

we would have paid $200 or more a night for that option.

I have news for you. You are spending far too much for far

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

too little. How happy would you be if I informed of the option to vacation at a luxury resort for the same price or ch

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

aper than the average hotel room?

Now imagine walking into your resort accommodations. Walking in the front door, you

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

would see a full kitchen off to your left. Straight ahead is the living room with a couch, chair, and love seat facing

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

an entertainment center. The whole place is decorated very tastefully. Windows line the far wall. The master bedroom

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s off to the left, with a whirlpool tub in the private bathroom. Just before walking into the second bedroom to your r

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ight, you notice a closet containing a washer and dryer.

Do you realize that those resort accommodations will cost yo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the same or less than much smaller hotel lodging? The price for a week at a luxury resort generally runs $600 - $1500

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

a week, or about $85-$215 a night. When you also consider the fact that your full kitchen can be used as a dining out

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

replacement, you've really got a money saving option.

So what's the catch? Resort rental is so cheap because there ar

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

thousands of timeshare owners who have purchased these units and are now trying to rent them out. Dozens of websites

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

are dedicated to just this -- helping timeshare owners rent out their unused resort units. Be aware that resorts rent

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ut units in full week increments. You can't use this option for an overnight business trip. That's what hotels are for

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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If you’ve ever developed severe muscle cramps during long-term exercise, the odds are that you never found out why it happened. Doctors in South Africa studied triathletes and found that most of the time, the muscles cramps were not caused by dehydration, thyroid disease, blocked blood flow, nerve damage, or mineral abnormalities. Here's what they found...

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