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The fire of the Spirit captivates hearts and pulls them Godward. Such was the case for Elisha. When Elijah passed by Elisha, the spirit of Elisha leapt within him. Tho

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ugh Elisha had been busy plowing with the oxen, upon being touched by Elijah’s God-given spiritual mantle, he immediately left the oxen and ran after Elijah (I K

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ngs 19:19-20). To obtain the fire of the Spirit, you will have to leave some things behind. Some burdensome relationships that are not edifying you spiritually will ha

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e to be cut off.

When Elisha sought Elijah’s permission to go back and kiss his father and mother, Elijah pretty much told him to go back home and never return

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

v. 20). Elijah did not have time for double-mindedness and misplaced affections. Yet Elisha managed to slay his oxen and get rid of that which was holding him back. So

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

etimes before you can go forward, you have to remove all distracting influences impeding your progress. Elisha’s oxen and plowing business were a distraction fro

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Elijah – the man appointed by God to be Elisha’s spiritual father. Only after the old is removed can the new be pursued.

Elijah was the man God

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

sed to call fire down from heaven (I Kings 18:36-39). When the fire of the Lord fell, the people saw it and their hearts turned back to God. Elisha no doubt saw the fi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e of God’s Spirit on Elijah and was compelled to follow him. Indeed, Elisha wanted a spiritual impartation from Elijah. As Elisha continued to follow Elijah on h

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s spiritual journey, he became increasingly positioned to receive from the man of God whatever the Lord may determine to give to him. This is not to say that there wer

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

not opportunities for Elisha to leave Elijah. In fact Elijah not only afforded Elisha several times to depart, but also sought to get rid of him on numerous occasions

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

(II Kings 2).

En route to Elijah’s liftoff and heavenly homecoming, Elijah told Elisha four times to stay behind and not to follow him further. Yet Elisha foll

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

wed Elijah until the end. The two passed through four places: Gilgal, Bethel, Jericho and Jordan (2 Kings 2:1-8). Seeing the persistence of Elisha, Elijah asked Elisha

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

what he could do for him (v. 9). Elisha asked for a double portion of Elijah’s spirit – a hard thing (v. 9-10). It was a hard thing in that receiving anoth

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r man’s spirit is not easy. It requires interaction, seeing eye to eye, and walking within the confines and perimeters of the ministerial office.

The mechanics

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f ministry, the guidelines for properly and effectively functioning in the ministry, and the heavenly vision all need to be transferred before the predecessor’s

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

eparture. Going onward, Elijah and Elisha talked (v. 11). The final requirement was that Elisha was to keep his eyes on Elijah, without which he would have missed his

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

lessing. Do away with and minimize your number of daily distractions. In the twinkling of an eye, when Elijah went up to heaven in a chariot of fire, Elisha cried good

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ye to his spiritual father and caught his ministerial mantel (v. 11-14). Experimenting with the mantle of Elijah, Elisha progressively became comfortable with it and e

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

entually performed twice as many miracles throughout his ministry as Elijah had performed. Indeed, the fire was transferred and the disciples multiplied through Elisha

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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