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    People who have been swept off their feet know the feeling. Love makes us all feel funny. That sense of giddy disorientation, unsinkable euphoria and complete obsession with a new love can be so overpowering, that it's hard
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    to imagine it's all about emotion. Now scientists are confirming there indeed may be a lot more going on in a body that's in love than simple, happy thoughts. In fact, a spate of research has shown what kind of chemical and
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    neurological activities occur at different stages of human and animal relationships. While the results hardly make love less mysterious, they do start to shed light on why it can make people feel so funny.

    DOPED UP

    Helen F
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    sher, a research professor of anthropology at Rutgers University , is among many scientists who believe the flush of a new love is enhanced by natural stimulants in the brain, dopamine and norepinphrine. She explains that hi
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    gh levels of these natural chemicals can make people lose their appetites and their desire for sleep, just by thinking about their new infatuations. "These are basic traits commonly associated with romantic love and with the
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    e natural stimulants," she says. "What else could explain the way you constantly think about a person, about the way you want to read them your bad poetry?"

    Further studies show that gushy romantic sensations may be similar
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    to the highs drug addicts feel when they're under the influence. Nora Volkow; the associate director for life sciences at Brookhaven National Laboratory in New York , has analysed the behaviours of drug addicts and people i
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    n love and found striking parallels. "When a person is passionately in love, it is extremely exciting and provocative, and if the loved one is not there, distressing," says Volkow. "When I see my drug addicted patients, it j
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    st clicks with me how similar the addiction is. "The fact that drug addiction and passionate love may trigger the same responses, signals to Volkow that drug addiction is especially dangerous since it taps into a natural sen
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    sation.

    STIRRING THE BRAIN

    She points out that recent studies show the same regions of the brain including the frontal cortex which is activated when a drug addict is high and when someone in love is looking at a picture o
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    a loved one. Researchers at University College in London recently recorded changes in the brains of people who described themselves as "truly and madly" in love. The researchers, Andreas Bartels and Semir Zeki used a functi
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    onal magnetic resonance imager to scan the brains of 17 lovehappy volunteers. When the team showed volunteers photos of their lovers, the results were dramatic. Four small areas of the brain lit up instantly the same areas t
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    hat have been shown to respond to euphoria-inducing drugs.

    Old friends, apparently, don't quite cause the same stir. Fisher is conducting similar studies and is scanning the brain activity of people newly in love.

    THREE ST
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    GES OF LOVE

    As most know; however, the rush people feel from new love usually doesn't last forever. And Fisher is also interested in understanding the biological stimulants and anthropological explanations for all phases of
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    love.

    She argues that there are three main stages to a love relationship: lust, romantic love and attachment. The first, she says, is "to get you looking for anything at all" and is driven by hormones like testosterone.

    T
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    e romantic love phase, which creates the brain chemical reactions described by the London researchers, serves to "force you to focus your mating energy on one person at a time."

    And the fmal, less steamy stage of attachment
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    is to ensure that any children produced by a love match has parents at least through its early years.

    Research shows there may also be chemicals associated with feelings of attachment. When researchers injected a natural c
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    hemical called oxytocin into the mice, the animals immediately formed attachments. When they injected chemicals that block the effect of oxytocin, Fisher says; the mice "avoided their partners and acted like cads."

    Recent s
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    udies have zeroed in on the chemistry of love, revealing what kind of chemical and neurological activities occur at different stages of human and animal relationships.

    Love is enhanced by natural stimulants to the brain, do
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    pamine and noreinphrine.

    Gushy romantic sensations similar to the high of drug addiction.

    Regions of the brain stirred when thinking of the loved one.

    The stages of lust, love and attachment are affected by body chemicals


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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