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The SA-8 GECKO is a single-stage, solid-fuel, short-range, low-altitude, all-weather SAM system. The TELAR (transporter erector launcher and radar) vehicle is a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

six-wheeled design designated BAZ-5937.

The driver's compartment at the front of the vehicle has accommodation for two, the driver and commander, with access

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to it via a hatch in the roof.

The engine is at the very rear. Four command-guided missiles are carried ready to launch, two either side. The main fire control

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

radar is at the rear of a one-man gunner-radar operator position and folds back 90 degrees to reduce the overall height of the vehicle for air transport and du

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ing high speed road travel. It is known that the radar operates in the H-band with a 360 degrees traverse and has a maximum range of 35 km. The complete conical

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

-scan radar installation of the GECKO has been assigned the NATO code name LAND ROLL.

Each battery also has two missile transloaders based on the same chassis

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

with a long coffin-like blunt pointed tarp roofed structure covering the cargo space and crane. When operating, the blunt point area is raised and the tarped st

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ructure is slid to the rear.

A total of 18 reloads in boxed sets of three are transferred to the TELARs by the hydraulic crane mounted centrally behind the veh

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

cle cab. In the Regiments Maintenance battery there is a single radar collimation vehicle using the same chassis. This has a collimation antenna which lies on b

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

oth sides of the vehicle and overhangs the rear during transit. In operation it is raised and mounted on each side of the hull directly behind the cab.

The SA-

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

8a (GECKO Mod 0) high acceleration missile (Factory Index number 9M33) has a launch weight of about 130 kg. Maximum speed is Mach 2.4, minimum altitude is 25 m,

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

maximum effective altitude 5000 m. The minimum range is 1500 m and the maximum range 12000 m. Against an F-4 Phantom target the warhead's lethal radius at low

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ltitude is 5 m and is fitted with proximity and contact fuses. In 1980 a newer missile, the SA-8b or GECKO Mod 1, was introduced into service. Contained in a re

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ctangular launch box it has improved guidance and speed characteristics to give an increased maximum range of 15000 m.

The warhead weight of both missiles is 1

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

9 kg. The reloading time is five minutes. Combat deployment time is four minutes with system reaction 26 seconds.

The surveillance radar of the LAND ROLL opera

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tes in the H band and has an effective range of around 30 kilometers against a typical target.

The tracking radar is of the pulsed type and it operates in the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

band with a range of 20 to 25 kilometers. The two I-band guidance radars make it possible to launch two missiles at the same target, each one responding to a d

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ifferent frequency to frustrate ECM.

Mounted on top of each missile guidance radar is an LLLTV/optical assist system for target tracking in low visibility and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

heavy ECM. LAND ROLL is also known to have a short-range target acquisition capability.

The vehicle is fully amphibious, being propelled in the water by two wa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ter jets at the rear of the hull. The vehicle is fitted with an air filtration and overpressure NBC system together with IR systems for the commander and driver

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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